The FRED Pickup is for neck and bridge positions -- suitable for solid, semi, and hollowbody guitars. DiMarzio FRED humbuckers are like the PAF Pro with more gain, mid EQ, and overtones.
The DiMarzio FRED gives you a wide, fat tone with more crank and growl. Also very responsive to picking so you can pick harder to shift from crunch to overdrive.
Joe Satriani was the first player to discover and exploit these qualities, and it's been his main bridge pickup ever since. FRED is really sensitive to changes in pick attack and control settings.

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